Application of 13544-44-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13544-44-0, name is 2,4-Dichloro-5-iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 2,4-dichloro-5-iodopyrimidine (compound 201) (80.00g, 0.291mol, 1.0eq.) was dissolved in ethanol (800 ml) was added triethylamine (88.18g, 0.873mol, 3.0eq.), and The mixture was then placed in an ice bath with stirring, when the temperature dropped to 0C-5C, dropwise addition of cyclopentylamine (49.50g, 0.582mol, 2.0eq.), addition was complete 30 minutes, and then maintaining the temperature at about 5C with stirring. Monitored by HPLC, 2,4-dichloro-5-iodo-pyrimidine as peak area ratio of less than 1%, the reaction was terminated. The reaction mixture was concentrated after adding ethyl acetate (300mL), water (300mL), extraction and liquid separation. Aqueous phase was extracted with ethyl acetate (200mL×2) and extracted. The combined organic phases, the organic phase was washed with saturated brine (200mL) was extracted, dried over anhydrous sodium sulfate. The organic phase was concentrated in vacuo, the residue was purified by silica gel column chromatography to give compound 2-chloro-N-cyclopentyl-5-iodopyrimidin-4-amine after isolation (87.88g, yield rate: 93.5%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13544-44-0, 2,4-Dichloro-5-iodopyrimidine.
Reference:
Patent; Guangzhou Kaisheng Beite Pharmaceutical Co., Ltd.; Cai, Xiong; Qian, Changgeng; Liu, Bin; Li, Junqi; Lin, Mingsheng; Qing, Yuanhui; Weng, Yunwo; Wang, Yanyan; Xue, Weicai; You, Huajin; Zhou, Shiqing; (67 pag.)CN105622638; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
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