Application of 2927-71-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of 2,4-dichloro-5-fluoropyrimidine 7a (0.83g, 5mmol) in THF (10mL) at 0C was slowly added THF solution of cyclopentylamine (0.74mL, 7.5mmol). The resulting mixture was stirred at 0C for 3h (monitored by TLC). The solvent was removed in vacuo and water (20mL) was added and extracted with CH2Cl2 (3×10mL). Combined organic phase was washed with brine, dried over anhydrous Na2SO4, filtered and concentrated. The crude product was purified by column chromatography on silica gel (dichloromethane/methanol 50:1) to give 8a (0.83g, 77%) as a solid.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine.
Reference:
Article; Qin, Wen-Wen; Sang, Chun-Yan; Zhang, Lin-Lin; Wei, Wei; Tian, Heng-Zhi; Liu, Huan-Xiang; Chen, Shi-Wu; Hui, Ling; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 174 – 184;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia