In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 130049-82-0, name is 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one, the common compound, a new synthetic route is introduced below. Recommanded Product: 130049-82-0
EXAMPLE 8 Preparation of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (Formula I), Using Microwave Radiation 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (5 g), 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole monohydrochloride (5.2 g), methanol (200 mL) and N-(1-methylethyl)-2-propanamine (4.16 g) were charged into a microwave reactor vessel. Microwave radiation was applied for 7 minutes (temperature raised to 70 C.). After completion of the reaction, solvent was distilled completely under vacuum. To the residue, water (25 mL) was added and the mixture was extracted with dichloromethane (3*25 mL). Combined organic layer was distilled under vacuum at 40 C. to afford a residue. To the residue, acetone (100 mL) was added and heated to reflux for 10 minutes. The mass cooled to 30 C., maintained for about 10-15 minutes, filtered and washed with acetone (5 mL). The solid was dried at 58 C. to afford 4.5 g of the title compound.
The synthetic route of 130049-82-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Padi, Pratap Reddy; Bollikonda, Satyanarayana; Akundi, Surya Prabhakar; Cherukupally, Praveen; Suthrapu, Sashikanth; Mohanarangam, Saravanan; Kandirelli, Venkat Kiran; Chellu, Malleswara Rao; Pagadala, Narasimha Rao; US2009/48272; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
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