Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5751-20-2, name is 2-(Methylthio)pyrimidin-4(3H)-one. A new synthetic method of this compound is introduced below., Product Details of 5751-20-2
B) 2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4(3H)-one To a solution of 2-(methylsulfanyl)pyrimidin-4(3H)-one (5.2 g) obtained in Step A in diethylene glycol dimethyl ether (50 mL) was added 1-methyl-1H-pyrazol-4-amine (4.1 g), the mixture was stirred overnight at 150°C, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (5.4 g). 1H NMR(300 MHz, DMSO-d6) delta 3.79 (3H, s), 5.62-5.78 (1H, m), 7.45 (1H, s), 7.63-7.78 (1H, m), 7.89 (1H, s), 8.47-8.75 (1H, m), 10.77 (1H, dd, J = 15.5, 8.7 Hz). MS (ESI+) : [M+H]+192.1.
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Reference:
Patent; Takeda Pharmaceutical Company Limited; TSUKAMOTO, Tetsuya; OHBA, Yusuke; YUKAWA, Takafumi; NAGAMIYA, Hiroyuki; KAMEI, Taku; TOKUNAGA, Norihito; SAITOH, Morihisa; OKABE, Atsutoshi; EP2832734; (2015); A1;,
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