With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.157335-93-8, name is 4,6-Dimethylpyrimidine-5-carboxylic acid, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.name: 4,6-Dimethylpyrimidine-5-carboxylic acid
step 9-To a mixture of A-5a (98 mg, assuming 100% purity, 0.21 mmol), 4,6-dimethyl-pyrimidine-5-carboxylic acid (48 mg, 0.32 mmol), EDCI (92 mg, 0.42 mmol), HOBt hydrate (65 mg, 0.48 mmol) at RT were added sequentially DCM (6 mL) and DIPEA (0.67 mL, 3.8 mmol). The mixture was stirred at RT overnight, quenched with saturated aqueous NaHCO3, and extracted with EtOAc. The combined extracts were dried (Na2SO4), filtered, and concentrated in vacuo. The residue was purified on a preparative SiO2 chromatography plate and developed with a solution of 60% DCM and 40% DCM/MeOH/28% aqueous NH4OH (60:10:1) to afford 40 mg of A-1 as a white powder: MS calc’d for C35H58N5O3 [M+H]+ 596; Found, 596.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,157335-93-8, 4,6-Dimethylpyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Roche Palo Alto LLC; US2009/281133; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia