Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 156-81-0, name is Pyrimidine-2,4-diamine. A new synthetic method of this compound is introduced below., Application In Synthesis of Pyrimidine-2,4-diamine
Reference Example 18 4-Amino-2-(t-butoxycarbonylamino)pyrimidine A 5.52 g portion of 2,4-diaminopyrimidine was added to 150 ml of t-butanol and dissolved by heating to about 60 C., and the solution was cooled to room temperature, mixed with 12.38 g of DIBOC and then stirred at room temperature for about 3 days.. The reaction mixture was evaporated under reduced pressure and the thus formed crude product was purified by a silica gel column chromatography to obtain 7.02 g of the title compound from chloroform-methanol-28% aqueous ammonia (200:9:1, v/v/v) elude as white crystals.
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Reference:
Patent; Yamanouchi Pharmaceutical Co. Ltd.; US6673799; (2004); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia