In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile, the common compound, a new synthetic route is introduced below. COA of Formula: C5H3ClN4
Step 8-14 4-amino-6-(l -(8-methyl- 1 -oxo-2 -phenyl- 1 ,2-dihydropyrrolo[ 1 ,2-a]pyrazin- 3 -yl)ethylamino)pyrimidine-5 -carbonitrile (90) A mixture of 8m (40 mg, 0.15 mmol), 4-amino-6-chloropyrimidine-5-carbonitrile (28 mg, 0.18 mmol) and triethylamine (30 mg, 0.3 mmol) in n-BuOH (1 mL) was reacted under N2 at reflux for 16 hours. The precipitate was collected by filtration, washed with cold n-BuOH and dried to afford Compound 90 as a white solid (38.2 mg, yield: 55%). MS (m/z): 386 (M+H)+. 1H NMR (400 MHz, DMSO-d6) delta: 7.72 (s, 1H), 7.43 (d, / = 7.2 Hz, 1H), 7.41-7.31 (m, 3H), 7.29-7.19 (m, 4H), 7.10 (s, 2H), 6.37 (s, 1H), 4.77-4.69 (m, 1H), 2.38 (s, 3H), 1.26 (d, / = 6.7 Hz, 3H).
The synthetic route of 60025-09-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DAI, Guangxiu; XIAO, Kun; JIA, Hong; VENABLE, Jennifer Diane; BEMBENEK, Scott Damian; WO2014/15675; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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