Adding a certain compound to certain chemical reactions, such as: 3993-78-0, 2-Amino-4-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3993-78-0, blongs to pyrimidines compound. Safety of 2-Amino-4-chloropyrimidine
Under argon atmosphere, 4-chloropyrimidin-2-amine 10d (0.61g, 4.72mmol,It was prepared by the method “WO2009158011, A1” disclosed in the patent application),Compound 10c (1.1g, 5.19mmol),[1,1?-bis (diphenylphosphino) ferrocene] palladium dichloride (173mg, 0.24mmol),Potassium carbonate (1.30 g, 9.44 mmol) was dissolved in 20 mL of a mixed solution of 1,4-dioxane and water (V / V = 5: 1), heated to 90 C, and stirred for 2 hours. Stop the reaction,It was cooled to room temperature, concentrated under reduced pressure, and the residue was purified with CombiFlash rapid preparator using eluent system A to obtain the title product 10e (753 mg), yield: 89.01%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3993-78-0, its application will become more common.
Reference:
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.; Lu Biao; Wang Shenglan; Zhang Caihua; He Feng; Tao Weikang; (36 pag.)CN110684020; (2020); A;,
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