Synthetic Route of 1445-39-2, Adding some certain compound to certain chemical reactions, such as: 1445-39-2, name is 2-Amino-5-iodopyrimidine,molecular formula is C4H4IN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1445-39-2.
Under nitrogen atmosphere sodium hydride (0.03 g, 0.73 mmol, 3.2 eq., 60% NaH in oil) was addedto a solution of 2-amino-5-iodopyrimidine (0.05 g, 0.23 mmol, 1.0 eq.) in dry THF (1 mL) at 0 C.Benzyl bromide (0.07 mL, 0.58 mmol, 2.5 eq.) was added at 0 C after 30 min. and the reactionmixture was then allowed to warm up to room temperature. After 19 h water (3 mL) and ethyl acetate(2 mL) were added and the water phase was washed with ethyl acetate (3 mL). The combined organicphase was washed with brine (5 mL), dried over Na2SO4, filtered and the solvent was removed underreduced pressure. The crude product was purified by column chromatography (hexane to hexane/ethylacetate, 10:1, Rf = 0.57) to give N, N-dibenzyl-5-iodopyrimidin-2-amine 2a (0.07 g, 78%) as acolorless solid (m.p.: 117 C). Crystals suitable for X-ray analysis were obtained from a hexane/ethylacetate solution.
According to the analysis of related databases, 1445-39-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Moeschwitzer, Vicki D.; Kariuki, Benson M.; Redman, James E.; Tetrahedron Letters; vol. 54; 34; (2013); p. 4526 – 4528;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia