Application of 16879-53-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16879-53-1, name is 2-Phenylpyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below.
A solution of 150 mg of 2-phenyl-4pyrimidinecarboxylic acid in 1 mL of thionyl chloride was heated at 70 C. for 1 hr, cooled to room temperature and the excess thionyl chloride removed by evaporation under reduced pressure to yield 145 mg of 2-phenyl-4-pyrimidinecarboxylic acid chloride which was used in the next step without further purification or characterization.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,16879-53-1, 2-Phenylpyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Neurogen Corporation; US5594141; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia