At the same time, in my other blogs, there are other synthetic methods of this type of compound,5399-92-8, 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine, and friends who are interested can also refer to it.
Synthetic Route of 5399-92-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5399-92-8, name is 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine. A new synthetic method of this compound is introduced below.
EXAMPLE 107; 4-(7-(benzyloxy)-lH-benzordlimidazol-2-yl)-l-(lH-pyrazolor3,4-dlpyrimidin-4- yl)piperidin-4-amine107 A. Methyl 4-(tert-butoxycarbonylamino)-l-(lH-pyrazolor3,4-dlpyrimidin-4- yl)piperidine-4-carboxylateTriethylamine (25.3 mL, 181.81 mmol) was added in one portion to a stirred suspension of methyl 4-(t°t-butoxycarbonylamino)piperidine-4-carboxylate (10.80 g, 41.82 mmol) and 4-chloro-lH-pyrazolo[3,4-d]pyrimidine (5.62 g, 36.36 mmol)** in ethanol (175 mL) at 2O0C under nitrogen. The resulting solution was stirred at 2O0C for 30 minutes and at 5O0C for 10 minutes. The solution was filtered and the filtrate was evaporated. The crude product was purified by flash silica chromatography, elution gradient 2 to 8% MeOH in DCM. Pure fractions were evaporated to dryness to afford methyl 4-(tert- butoxycarbonylamino)- 1 -( 1 H-pyrazo Io [3 ,4-d]pyrimidin-4-yl)piperidine-4-carboxylate (9.94 g, 72.6 %) as a cream dry film, m/z (ESI+) M+ = 377; HPLC tR = 1.24 min; IH NMR (399.9 MHz, DMSO-d6) delta 1.41 (9H, s), 1.92 – 1.97 (2H, m), 2.07 – 2.10 (2H, m), 3.57 (2H, m), 3.63 (3H, s), 4.34 (IH, s), 7.53 (IH, s), 8.24 (IH, s), 8.30 (IH, s), 13.52 (IH, s).H= * Commercially available from Chontech (catalogue number: 07044)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5399-92-8, 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB; WO2008/75109; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia