Synthetic Route of 2227-98-7, Adding some certain compound to certain chemical reactions, such as: 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine,molecular formula is C6H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2227-98-7.
Compound (XII) (457 mg, 3.10 mmol) is stirred in water/ethanol (4:1, 22.5 ml) and treated with9-deazaadenine (378 mg, 2.82 mmol) and formaldehyde solution (0.21 ml, 38 %). The mixtureis stirred at ambient temperature for 3 days. A solution of sulfuric acid (2.8 ml, 1M) is added.Ethanol (5 ml) is added. The mixture is cooled to 0 C and stirred for 15 minutes. The resultingslurry is filtered and the crystals dried to give 548mg tan solid. A portion of this solid (300 mg) isstirred in water (approximately 10 ml) with Amberlite FPA91-OH resin (approximately 2 g) for 30minutes. The resin is filtered and the solution evaporated to give 143 mg white solid ((3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimid in-7-yl)methyl)-4-(methylthiomethyl)pyrrolid in-3-ol which isused in the next steps).(3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(methylthiomethyl)pyrrolidin-3-ol (50 mg, 0.17 mmol) is dissolved in water (1 .0 ml) and treated with sulfuric acid (0.17 ml, 1 M, 1.0 eq). IPA (0.4 ml) is added and the resulting solution stored at 4 C resulting in formation of an oil phase. The mixture is warmed to give a solution, treated with ethanol (approximately 0.2 ml) and stored at 4 C overnight resulting in precipitation of solids from solution. The solid is filtered on filter paper and dried under vacuum.
According to the analysis of related databases, 2227-98-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CALLAGHAN INNOVATION RESEARCH LIMITED; EVANS, Gary Brian; KELLY, Peter Michael; TYLER, Peter Charles; WO2014/73989; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia