In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5750-74-3, name is 2,5-Dichloro-4-methoxypyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 5750-74-3
General procedure: Example 8: 6-Chloro-5-(5-chloro^t-(methylamino)pyrimidin-2-ylamino)-2- methylisoindolin-l-one A mixture of 5-amino-6-chloro-2-methylisoindolin-l-one (61 mg, 0.31 mmol), 2,5-dichloro-4-methoxypyrimidine (55 mg, 0.31 mmol) and pTSA (59 mg, 0.31 mmol) in dioxane (4 mL) was heated to 100 C for 18 h. DCM (10 mL) and saturated aqueous NaHC03 (10 mL) were added and the mixture was passed through a hydrophobic frit. The solvent was removed in vacuo and purification of the residue via reversed phase preparative HPLC gave 6-chloro-5-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-2- methylisoindolin-l-one (26 mg, 25%) as an off-white solid. LCMS (10 cm ESCI Formic MeCN): [M + H]+ = 338 at 2.83 min. ? NMR (400 MHz, d6- DMSO): ? 8.46 (s, IH), 8.29 (s, IH), 8.01 (s, IH), 7.73 (s, IH), 7.41 (q, J 4.6, IH), 4.48 (s, 2H), 3.08 (s, 3H), 2.91 (d, J4.6, 3H).
The synthetic route of 5750-74-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BAKER-GLENN, Charles; CHAMBERS, Mark; CHAN, Bryan K.; ESTRADA, Anthony; SWEENEY, Zachary Kevin; WO2013/79505; (2013); A1;,
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