With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10397-13-4, name is 4-(4,6-Dichloropyrimidin-2-yl)morpholine, molecular formula is C8H9Cl2N3O, molecular weight is 234.08, as common compound, the synthetic route is as follows.Product Details of 10397-13-4
Example 18 6-Methoxy-2-morphoIin-4-yl-f4,5’lbipyrimidinyl-2′-yIamine £98}To Intermediate A in DMF was added sodium methoxide in methanol and stirred at room temperature overnight. EtO Ac/brine extraction yielded 4-(4-Chloro-6- methoxy-pyrimidin-2-yl)-morpholine.4-(4-Chloro-6-methoxy-pyrimidin-2-yl)-morpholine was reacted with 2- aminopyrimidine-5-boronic acid pinacol ester in General Procedure A to yield the title compound.NMR: (CDCl3, 400MHz): 3.71 (t, 4H, 2xCH2, J = 4.7Hz); 3.80 (t, 4H, 2xCH2, J = 4.6Hz); 3.86 (s, 3H, CH3); 5.19 (br s, 2H, NH2); 6.22 (s, IH, ArH); 8.82 (s, 2H, 2xArH). MS: (ESI+): MH+ = 289.12
At the same time, in my other blogs, there are other synthetic methods of this type of compound,10397-13-4, 4-(4,6-Dichloropyrimidin-2-yl)morpholine, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; WO2009/66084; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia