Application of 19875-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19875-04-8, name is 2-Methylpyrimidin-4(3H)-one, molecular formula is C5H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: 6-[5-(5-Fluoro-2-oxo-2H-pyridin-l-ylmethyl)-pyridin-3-yl]-l-methyl-3,4-dihydro-lH- quinolin-2-one; To a solution of 6-(5 -chloromethyl-pyridin-3 -yl)- 1 -methyl-3 ,4-dihydro- 1 H-quinolin-2-one (intermediate A-3 [B]) (0.05 g, 0.147 mmol) in DMF (1 mL) was added 5-fluoro-lH-pyridin-2- one (0.019 g, 0.174 mmol) and K2C03 (0.048 g, 0.349 mmol) and the reaction mixture was stirred at room temperature over night. The mixture was evaporated to dryness and the residue purified by silica gel flash chromatography eluting with a 0 to 5% MeOH-DCM gradient to give 6-[5 -(5 -fluoro-pyridin-2-yloxymethyl)-pyridin-3 -yl] – 1 -methyl-3 ,4-dihydro- 1 H-quinolin-2-one (0.016 g, 25 %), as colorless solid,
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19875-04-8, 2-Methylpyrimidin-4(3H)-one.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KUHN, Bernd; MAERKI, Hans, P.; MAYWEG, Alexander, V.; TAN, Xuefei; WO2014/139981; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia