Electric Literature of 3934-20-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3934-20-1, name is 2,4-Dichloropyrimidine, molecular formula is C4H2Cl2N2, molecular weight is 148.9781, as common compound, the synthetic route is as follows.
Compound a (5 g, 1.0 eq), b-1 (5 g, 0.9 eq),Aluminum trichloride (5g, 1.0eq) was added to the 100mL eggplant bottle.Reaction at 80 C, TLC detection reaction is complete,Then, ice water was added and stirred for 5 min, suction filtered, and the filter cake was rinsed with 50 mL of water.Intermediate c-1 was obtained by column chromatography, and the yield of 7 g was 75.3%.
The chemical industry reduces the impact on the environment during synthesis 3934-20-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Liaoning University; Chen Ye; Ding Shi; Liu Ju; Ji Jingchao; Hao Xuechen; Liu Yutong; Li Jie; Zhang Mingjuan; Gong Yilin; (29 pag.)CN110283162; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia