Application of 22536-61-4, Adding some certain compound to certain chemical reactions, such as: 22536-61-4, name is 2-Chloro-5-methylpyrimidine,molecular formula is C5H5ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22536-61-4.
A solution of the compound (556 mg, 1.0 mmol) obtained in Example 16-5), 2-chloro-5-methylpyrimidine (193 mg, 1.5 mmol), tetrakis(triphenylphosphine)palladium(0) (231 mg, 0.2 mmol), and potassium carbonate (276 mg, 2 mmol) in dimethoxyethane (4 mL) and water (1 mL) was stirred at 130°C for 1.5 h under microwave irradiation. The reaction mixture was cooled to room temperature, saturated aqueous sodium hydrogencarbonate was added to the reaction mixture, the mixture was extracted with dichloromethane, and the organic layer was washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (Isco Combiflash, 40 g, methanol:ethyl acetate = 0:100 to 20:80, gradient) to obtain the title compound (298 mg, 57percent) as a brown oily substance. 1H-NMR (400 MHz, CDCl3) delta: 0.05 (3H, s), 0.07 (3H, s), 0.91 (9H, s), 1.19 (3H, s), 1.49-1.52 (2H, m), 1.58-1.67 (2H, m), 2.34 (3H, s), 2.50 (1H, ddd, J = 15.6, 8.0, 2.2 Hz), 2.63 (1H, ddd, J = 15.6, 7.7, 2.2 Hz), 3.40 (2H, s), 3.50 (1H, d, J = 10.2 Hz), 3.54 (1H, d, J = 10.2 Hz), 4.06 (1H, ddd, J = 14.6, 8.0, 2.2 Hz), 4.31 (1H, ddd, J = 14.6, 7.7, 2.2 Hz), 7.17 (2H, dt, J = 8.7, 2.0 Hz), 8.32 (2H, dt, J = 8.7, 2.0 Hz), 8.62 (2H, s)
According to the analysis of related databases, 22536-61-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Daiichi Sankyo Company, Limited; MORI, Makoto; FUJII, Kunihiko; INUI, Masaharu; BABA, Takayuki; ONISHI, Yukari; AOYAGI, Atsushi; EP2700643; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia