Synthetic Route of 51-20-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.51-20-7, name is 5-Bromouracil, molecular formula is C4H3BrN2O2, molecular weight is 190.9828, as common compound, the synthetic route is as follows.
To a mixture of 5-bromo-1H-pyrimidine-2,4-dione (400.6 mg, 2.1 mmol, 1.0 eq) and 1-([1,1?-biphenyl]-3-yl)piperazine (500 mg, 2.1 mmol, 1.0 eq) in DMSO (10.00 mL) was addedpotassium fluoride (182.8 mg, 3.15 mmol, 1.5 eq). The resulting mixture was stirred at 110 C for 8 hours, cooled to room temperature, poured into water and the gray precipitate collected by suction filtration. The gray solid was washed with 100 mL of 1:1 EtOAc: petroleum ether to give 5-(4-([ 1,1 ?-biphenyl]-3 -yl)piperazin- 1 -yl)pyrimidine-2,4(1H,3H)-dione (500.0 mg, 1.4mmol, 68.3% yield) as a gray solid. LCMS Method B (ESI+): Expected m/z 349.1 (M+1) found m/z 349.1 (M+1), RT: 2.16 Mm.
Statistics shows that 51-20-7 is playing an increasingly important role. we look forward to future research findings about 5-Bromouracil.
Reference:
Patent; VYERA PHARMACEUTICALS, LLC; WELSCH, Matthew; HOPPER, Allen, T.; THOMAS, Stephen, B.; (136 pag.)WO2019/32458; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia