Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3438-46-8, name is 4-Methylpyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C5H6N2
A mixture of NaNH2 (46.1 g, 1.182 mol), hexamethyldisilazane (171.5 g, 1.063 mol), and diglyme (200mL) was stirred at 0 C for 2 h. Then, a mixture of 4-methylpyrimidine (4) (40.0 g, 0.425 mol),4-fluorobenzoic acid ethyl ester (14) (71.5 g, 0.425 mol), and diglyme (200 mL) was added dropwise at0 C, and the reaction mixture was stirred at the same temperature for 2 h. Next, 2 mol/L HCl aqueoussolution (1360 mL) was added to reach pH 7~9, and the mixture was diluted with water (600 mL). Theresulting precipitate was collected by filtration, washed with water (1600 mL), and dried under reducedpressure at 40 C to provide the title compound 15 (84.16 g, 92%) as a yellow solid
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Reference:
Article; Ohta, Shuji; Saito, Takahisa; Kato, Jun-Ya; Sato, Shuichiro; Hayashi, Hiroyuki; Hasumi, Koichi; Heterocycles; vol. 94; 5; (2017); p. 938 – 948;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia