Related Products of 171887-03-9 , The common heterocyclic compound, 171887-03-9, name is N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide, molecular formula is C5H4Cl2N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-Amino-4,6-dichloro-5-formamidopyrimidine (0.8g; 3.8mmol) and DIPEA (1.7mL; 10.0mmol) were added to a solution of 4-amino-3-hydroxy-1-trityloxymethylphospholane 1-oxide 18 (1.0g; 2.5mmol) in n-butanol (25mL). The reaction mixture was stirred for 16h at 130C and evaporated. The residue was treated 16h at 60C with concentrated hydrochloric acid/ methanol 1/ 10 (25mL), diluted with water (100mL) and treated with Dowex H+ (10g). The resin was filtered off and washed with methanol (100mL) and water (100mL). The product was washed off of the resin with 5% aqueous ammonia (100mL), evaporated, purified by preparative HPLC (isocratically water) and freeze-dried from water to yield 0.36g (48%) of white lyofilisate. HRMS (FAB) calcd for C10H15N5O4P (M+H)+ 300.0862, found 300.0861. IR numax (KBr) 3480, 3438, 3318, 3215, 3138, 3119, 2732, 1747, 1688, 1658, 1641, 1628, 1589, 1578, 1544, 1480, 1421, 1400, 1386, 1324, 1224, 1166, 1062, 1050, 1036, 778, 734, 634. NMR data-see Tables 2-4.
The synthetic route of 171887-03-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Pav, Ond?ej; Zbornikova, Eva; Bud??insky, Milo?; Rosenberg, Ivan; Tetrahedron; vol. 69; 43; (2013); p. 9120 – 9129;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia