9/28 News Some scientific research about 111196-81-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 111196-81-7, 2-Chloro-5-ethylpyrimidine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111196-81-7, name is 2-Chloro-5-ethylpyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Chloro-5-ethylpyrimidine

<142> Preparation Example l:Synthesis of l-(5-methyl-pyrimidin-2-yl )- din-4- l<144> Under a nitrogen atmosphere, in a 500ml flask, 9.6g of 4- hydroxypiper idine and 250ml of 2:1 acetonitr i le/dist i 1 led water-solution were placed, stirred and dissolved. Then, 19.5ml of di isopropylethylamine and 11.2g of 2-chloro-5-ethylpyr imidine were added thereto, followed by heating and reflux for 2.5 days or more. The temperature was lowered to a room temperature, and the resultant product was dissolved in 200ml of IN HC1 aqueous solution, and washed with 200ml of ethyl acetate. The aqueous layer was adjusted to pH 7 by using IN NaOH aqueous solution, and was extracted with 200mL of ethyl acetate. The organic layer was dried with anhydrous magnesium sulfate and vacuum-dried so as to provide a target compound. H NMR (400MHz, CDC13): 8.18(2H, s), 4.37-4,48(2H, m), 3.91-4.0K 1H, m) ,3.22-3.3K2H, m), 2.42-2.5K2H, m) , 1.49-1.99(4H, m) , 1.17-1.2K3H, m).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 111196-81-7, 2-Chloro-5-ethylpyrimidine.

Reference:
Patent; HYUNDAI PHARM CO., LTD.; PARK, Yong Kyu; BANG, Sung Hun; KIM, Jin Woong; LEE, Han Kyu; KIM, Jae Hyun; SON, Chang Mo; LEE, Jun Hee; SHIN, Chang Yong; LEE, Jong Chan; RHEE, Jae Keol; WO2012/11707; (2012); A2;,
Pyrimidine | C4H4N2 – PubChem,
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