Adding a certain compound to certain chemical reactions, such as: 22536-61-4, 2-Chloro-5-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 22536-61-4, blongs to pyrimidines compound. Product Details of 22536-61-4
A 3-necked 3 L RBF was fitted with a reflux condenser, a temperature controller and a septum and was charged with 2-chloro-5-methylpyrimidine (81 mL, 778 mmol), potassium vinyltrifluoroborate (156 g, 1167 mmol), triphenylphosphine (18.02 mL, 78 mmol), and cesium carbonate (156 mL, 1945 mmol). Water (1565 mL) was added, and the mixture was stirred for 2 min and then THF (244 mL) was added. Argon was sparged through the mixture for 5 min and then palladium (II) chloride (1.72 g, 38.9 mmol) was added. The reaction was further sparged with argon for 5 min. The temperature was raised to 62 °C and stirring was continued until completion. The reaction was cooled to RTand filtered through two Whatman GF/F filter cups, rinsing with diethyl ether. The mixture was transfered to a separatory funnel and the layers were separated. The aqueous layer was further extracted with diethyl ether (4X). The combined organic layers were dried over anhydrous magnesium sulfate and partially concentrated in vacuo at 20 °C and 115 torr for an extended period of time to give an orange liquid. The initial product was purified by Kugelrohr distillation to provide 405.01 (65.4 g, 70percent yield) as a light yellow oil. LCMS- ESI (pos.) m/z: 121.1 (M+H)+.
The synthetic route of 22536-61-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HORNE, Daniel B.; HOUZE, Jonathan; KALLER, Matthew R.; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; NISHIMURA, Nobuko; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YANG, Kevin; YEH, Wen-Chen; (700 pag.)WO2018/97945; (2018); A1;,
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