Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 69034-08-8, name is 5-(Trifluoromethyl)pyrimidin-2-amine. A new synthetic method of this compound is introduced below., Computed Properties of C5H4F3N3
To a stirred solution of 5-(trifluoromethyl)pyrimidin-2-amine(A36, 4.5 g, 27.60 mmol) in l,4-dioxane(80 mL) was added 3-bromo-2-oxopropanoic acid(A15, 6.87 g , 41.4 mmol .The reaction mixture was heated at 100 C for 16 h. After completion of reaction mixture was concentrated under reduced pressure. The crude product was triturated with ethyl acetate and dried to afford 6-(trifluoromethyl)imidazo[l,2-a]pyrimidine-2-carboxylic acid A37 and A38 as dark brown mixture Yield: 7.0 g,(crude). LC-MS m/z : 229.96[M-H]
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Reference:
Patent; JUBILANT BIOSYS LIMITED; VADIVELU, Saravanan; RAJAGOPAL, Sridharan; BURRI, Raghunadha Reddy; GARAPATY, Shivani; SIVANANDHAN, Dhanalakshmi; THAKUR, Manish Kumar; NATARAJAN, Tamizharasan; SWAMY, Indu N; NAGARAJU, Nagendra; KANAGARAJ, Subramaniam; MOHD, Zainuddin; SARKAR, Sayantani; SAMANTA, Swapan Kumar; ., Hariprakash; (284 pag.)WO2019/102494; (2019); A1;,
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