As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 2227-98-7
[0035] Example A. Synthesis of 2-[({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7- yljmethyl) amino] ethan-l-ol (A.1). (0059) (0060) [0036] 2-[ ({4-Amino-5H-pyrrolo[3, 2-dJpyrimidin- 7-yl }methyl) amino] ethan-l-ol (A.1). 2-Aminoethanol (0.099 mL, 1.64 mmol), 9-deazaadenine (0.220 g, 1.64 mmol) and aq. formaldehyde solution (37%, 0.15 mL, 1.99 mmol) were stirred together in tert-butanol (3 mL) at 70 C for 16 h. Silica gel was added to absorb all the solvent then the solvent was evaporated and the residue purified by chromatography on silica gel (CHCl3-MeOH-28% aq.NH4OH, 70:25:5). Fractions containing product were evaporated and the residue chromatographed again on silica gel (2-PrOH-28% aq. NH4OH, 92:8) to give A.1 as a colourless solid (0.101 g, 30%). NMR (500 MHz, CD3OD): delta 8.16 (s, 1H), 7.47 (s, 1H), 3.95 (s, 2H), 3.68 (t, J = 5.6 Hz, 2H), 2.78 (t, J = 5.6 Hz, 2H). 13C NMR (125.7 MHz, CD3OD, centre line delta 49.0): delta 152.1 (C), 150.9 (CH), 146.6 (C), 129.0 (CH), 1 15.4 (C), 114.4 (C), 61.6 (CH2), 51.6 (CH2), 43.4 (CH2). ESI-HRMS calcd for C9H14N50+, (M+H) 208.1 193, found 208.1 192.
With the rapid development of chemical substances, we look forward to future research findings about 2227-98-7.
Reference:
Patent; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; SCHRAMM, Vern, L.; CLINCH, Keith; GULAB, Shivali, Ashwin; WO2015/123101; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia