Synthetic Route of 153435-63-3 ,Some common heterocyclic compound, 153435-63-3, molecular formula is C16H30N2Sn, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
i) A solution of 3-(tributylstannyl)pyridine (0.449 g, 1.22 mmcl) and methyl 5-bromofuran-2-carboxylate (0.250 g, 1.22 mmol) in DMF (13 mL) was degassed with Ar. CsF (0.556 g, 3.66 mmol), CuCI (0.016 g,0.159 mmcl) and tetrakis(triphenylphosphine)palladium (0.071 g, 0.061 mmol) were added and the RM was heated at 110 C by microwave irradiation for 1 h. The RM was diluted with water (50 mL) and extracted with EtOAc (2x 50 mL). The combined organic layer was washed with brine (2x 50 mL), dried over Na2SO4 and concentrated in vacuo. FC (EtOAc/heptane 1:19 -> 4:6) afforded INT-IOA (0.215 g, 1 .06 mmol, 87%) as a pale yellow solid. LCMS: calc. for [M-f-H]=204.06, found 204.2.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,153435-63-3, its application will become more common.
Reference:
Patent; GRUeNENTHAL GMBH; NARDI, Antonio; RATCLIFFE, Paul; CRAAN, Tobias; HERTRAMPF, Thorsten; LESCH, Bernhard; KIME, Robert; STEINHAGEN, Henning; WO2015/161928; (2015); A1;,
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