Related Products of 1032452-86-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of methyl p-aminobenzoate hydrochloride (4.24 g, 22.60 mmol) and p-toluenesulfonicacid (3.90 g, 22.60 mmol) in 1, 4-dioxane (80 mL) was added 1 (5.0 g, 20.52 mmol). The reaction wasmonitored by TLC and stirred at 85 C for 3 h. After cooling to room temperature, 6 mL of ammoniawater was added dropwise followed by addition of 80 mL of H2O. The mixture was stirred at roomtemperature overnight with the resulting precipitate being filtered. The filter residue was washed withwater and dried to give compound 2 (5.85 g, yield: 79%) as an orange-yellow solid, which was usedin the following reaction without further purification. 1H NMR (600 MHz, DMSO-d6) delta 9.85 (s, 1H),8.61 (d, J = 8.1 Hz, 1H), 8.42 (d, J = 5.3 Hz, 1H), 8.34 (s, 1H), 8.02 (d, J = 8.4 Hz, 2H), 7.93 (d, J = 8.4 Hz,2H), 7.56 (d, J = 8.3 Hz, 1H), 7.33-7.28 (m, 2H), 7.24 (t, J = 7.5 Hz, 1H), 3.91 (s, 3H), 3.84 (s, 3H).
According to the analysis of related databases, 1032452-86-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Dong, Hang; Yin, Hao; Zhao, Chunlong; Cao, Jiangying; Xu, Wenfang; Zhang, Yingjie; Molecules; vol. 24; 13; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia