Electric Literature of 89793-12-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate. A new synthetic method of this compound is introduced below.
Step 1: A mixture of ethyl 2-chloropyrimidine-5-carboxylate (1.86 g, 10 mmol), compound 1 (4-amino-l-Boc-piperidine, 3.00 g, 15 mmol), and NEt3 (3.0 g, 30 mmol) in 1,4-dioxane (20 mL) was stirred at 95°C overnight. The mixture was concentrated, and EA (60mL) and aqueous citric acid (60 mL) were added to the mixture followed by stirring the mixture for 30 min. The organic layer was collected, dried and concentrated to get compound 2 (3.4 g, yield: 97percent) as a light yellow solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,89793-12-4, Ethyl 2-chloropyrimidine-5-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; SHEARSTONE, Jeffrey, R.; JARPE, Matthew, B.; (152 pag.)WO2016/57779; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
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