696-82-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 696-82-2, name is 2,4,6-Trifluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
A solution of 2,4,6-trifluoropyrimidine (278 mg, 2.07 mmol) in Et20 (10 mL) is cooled to -20 C and is treated, dropwise, with a solution of tert-butyl 4-[[4-[(1S)-1- aminoethyllphenyllmethyllpiperazine-1-carboxylate (600 mg, 1.88 mmol) in Et20 (10 mL). The resulting mixture is stirred at -20 C for 1 hour and is then allowed to warm to room temperature and is stirred overnight. The solids are removed by filtration and arewashed with additional Et20. The filtrate is washed with water, using a small portion of NaC1 additive to reduce emulsification, and the aqueous layer is back-extracted with Et20 (lx) and CH2C12 (lx). The combined organic extracts are then dried (Na2SO4), filtered,and concentrated to give a crude product that is purified by silica gel chromatographyeluting with 20-60% EtOAc/hexanes to give the title compound as a pale yellow oil (606 mg, 1.40 mmol, 74%). ES/MS (mlz): 434 (M+H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 696-82-2, 2,4,6-Trifluoropyrimidine.
Reference:
Patent; ELI LILLY AND COMPANY; LUMERAS AMADOR, Wenceslao; BAUER, Renato A.; BOULET, Serge Louis; BURKHOLDER, Timothy Paul; GILMOUR, Raymond; HAHN, Patric James; CARBALLARES MARTIN, Santiago; RANKOVIC, Zoran; (80 pag.)WO2017/213910; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia