Gao, Ping; Song, Shu; Wang, Zhao; Sun, Lin; Zhang, Jian; Pannecouque, Christophe; De Clercq, Erik; Zhan, Peng; Liu, Xinyong published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs》.Application of 3934-20-1 The article contains the following contents:
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are widely used in combination therapies against HIV-1. As a continuation of authors’ efforts to discover and develop ”me-better” drugs of DAPYs, novel diarylpyrimidine derivatives I (R = Ph, 2-furyl, 3-pyridyl, etc.) were designed, synthesized and evaluated for their anti-HIV activities in MT-4 cells. All the compounds demonstrated strong inhibition activity against wide-type HIV-1 strain (IIIB) with EC50 values in the range of 2.5 nM ~0.93μM. Among them, compounds I (R = 4-pyridyl, 3-pyridyl) were the most potent ones which showed anti-HIV-1IIIB activity much superior than that of nevirapine, comparable to efavirenz and etravirine. What’s more, some compounds also showed low nanomole activity against some mutant strains such as K103N and E138K. The selected compound I (R = 4-pyridyl) was also evaluated for the activity against reverse transcriptase (RT), and exhibited submicromolar IC50 values indicating that this series compounds are specific RT inhibitors. Preliminary structure-activity relationships and modeling studies of these new analogs provide valuable avenues for future mol. optimization. In the experiment, the researchers used 2,4-Dichloropyrimidine(cas: 3934-20-1Application of 3934-20-1)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Application of 3934-20-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia