AlNeyadi, Shaikha S.; Adem, Abdu; Amer, Naheed; Ghattas, Mohammad A.; Atatreh, Noor; Salem, Alaa A.; Abdou, Ibrahim M. published their research in Results in Chemistry in 2021. The article was titled 《Activation of the GLP-1 receptor by chloropyrimidine derivatives》.COA of Formula: C4H2Cl2N2 The article contains the following contents:
The anti-diabetic activities of a series of chloropyrimidine derviativeswere investigated after they were designed, synthesized, and docked against the GLP-1 receptor target. In comparison to exenatide, which was utilized as a reference drug, the three chloropyrimidine synthesized compounds I, II and III exhibited potent in vitro and in vivo antidiabetic activities. Interestingly, compounds I, II and III showed to be the most effective in lowering blood glucose levels and led to even higher glucose uptake than the reference drug, exenatide. Consistent with the in vitro and in vivo data, compounds II and III had the lowest docking energy scores (Glide-XP score = 5.1 kcal/mol) and the greatest ligand efficiency score (> – 0.40 kcal/mol) among all docked compounds These findings give up new possibilities for the development of high-efficacy compounds to treat hyperglycemia. The experimental process involved the reaction of 4,6-Dichloropyrimidine(cas: 1193-21-1COA of Formula: C4H2Cl2N2)
4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.COA of Formula: C4H2Cl2N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia