Application of 3934-20-1In 2020 ,《Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors》 appeared in Bioorganic Chemistry. The author of the article were Vettorazzi, Marcela; Insuasty, Daniel; Lima, Santiago; Gutierrez, Lucas; Nogueras, Manuel; Marchal, Antonio; Abonia, Rodrigo; Andujar, Sebastian; Spiegel, Sarah; Cobo, Justo; Enriz, Ricardo D.. The article conveys some information:
Sphingosine-1-phosphate is now emerging as an important player in cancer, inflammation, autoimmune, neurol. and cardiovascular disorders. Abundance evidence in animal and humans cancer models has shown that SphK1 is linked to cancer. Thus, there is a great interest in the development new SphK1 inhibitors as a potential new treatment for cancer. In a search for new SphK1 inhibitors we selected the well-known SKI-II inhibitor as the starting structure and we synthesized a new inhibitor structurally related to SKI-II with a significant but moderate inhibitory effect. In a second approach, based on our mol. modeling results, we designed new structures based on the structure of PF-543, the most potent known SphK1 inhibitor. Using this approach, we report the design, synthesis and biol. evaluation of a new series of compounds with inhibitory activity against both SphK1 and SphK2. These new inhibitors were obtained incorporating new connecting chains between their polar heads and hydrophobic tails. On the other hand, the combined techniques of mol. dynamics simulations and QTAIM calculations provided complete and detailed information about the mol. interactions that stabilize the different complexes of these new inhibitors with the active sites of the SphK1. This information will be useful in the design of new SphK inhibitors. The experimental part of the paper was very detailed, including the reaction process of 2,4-Dichloropyrimidine(cas: 3934-20-1Application of 3934-20-1)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 3934-20-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia