Dreher, Spencer D.; Ikemoto, Norihiro; Gresham, Venita; Liu, Jinchu; Dormer, Peter G.; Balsells, Jaume; Mathre, David; Novak, Thomas J.; Armstrong, Joseph D. published an article in Tetrahedron Letters. The title of the article was 《Highly selective synthesis of 2-substituted-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid derivatives using a novel protected dihydroxyfumarate》.Recommanded Product: 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid The author mentioned the following in the article:
A high yielding (50-96%) route to 2-substituted-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid derivatives, e.g. I, has been developed using a rationally designed dihydroxyfumarate derivative The fully unprotected pyrimidinone heterocycle II was prepared in quant. yield upon treatment of I with HCl. In the experiment, the researchers used 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2Recommanded Product: 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid)
5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid(cas: 62222-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Recommanded Product: 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia