302964-08-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 302964-08-5, name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, molecular formula is C16H13Cl2N5OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, 7(1.00 g, 2.54 mmol), piperazine (2.19 g, 25.4 mmol),N,N-diisopropylethylamine (0.84 mL, 5.07 mmol) was dissolved in anhydrous 1,4-dioxane (30 ml) and refluxed for 12 h.The oil obtained by distillation under reduced pressure was washed with water / methanol, methanol / ether to give an off white solid.The crude product was recrystallized from diethyl ether to give compound 8 (0.82 g, 73%)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 302964-08-5, 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; China Pharmaceutical University; You Qidong; Jiang Zhengyu; Wang Yan; Jin Yuhui; Lu Mengchen; Xu Xiaoli; Guo Xiaoke; (21 pag.)CN109761970; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia