Application In Synthesis of 4,6-Dichloropyrimidin-2(1H)-oneOn June 14, 1989, Huebsch, Walter; Pfleiderer, Wolfgang published an article in Helvetica Chimica Acta. The article was 《Pteridines. Part XLI. Synthesis and properties of 6,7,8-trimethyl-4-thiolumazine》. The article mentions the following:
The first representative I of the 8-substituted 4-thiolumazine series has been synthesized. 4,6-Dichloropyrimidin-2(1H)-one was converted into 4-chloro-6-(methylamino)pyrimidin-2(1H)-one, then the Cl atom was displaced by the thioxo group followed by a coupling reaction with ClC6H4N2+Cl- to introduce the necessary N-function into the 5-position. Reduction of the p-chlorophenylazo group leads to 6-(methylamino)-4-thiouracil-5-amine which on condensation with diacetyl gives I. The phys. properties of I are compared with the 2-thio analog and with 6,7,8-trimethyllumazine indicating that I possesses the highest acidity and the longest UV absorption. The experimental process involved the reaction of 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9Application In Synthesis of 4,6-Dichloropyrimidin-2(1H)-one)
4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 4,6-Dichloropyrimidin-2(1H)-one
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia