Reference of 2,4-DichloropyrimidineIn 2021 ,《Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp》 appeared in Scientific Reports. The author of the article were Laiolo, Jeronimo; Lanza, Priscila Ailin; Parravicini, Oscar; Barbieri, Cecilia; Insuasty, Daniel; Cobo, Justo; Vera, D. Mariano Adolfo; Enriz, Ricardo Daniel; Carpinella, Maria Cecilia. The article conveys some information:
P-gp-associated multidrug resistance is a major impediment to the success of chemotherapy. With the aim of finding non-toxic and effective P-gp inhibitors, we investigated a panel of quinolin-2-one-pyrimidine hybrids. Among the active compounds, two of them significantly increased intracellular doxorubicin and rhodamine 123 accumulation by inhibiting the efflux mediated by P-gp and restored doxorubicin toxicity at nanomolar range. Structure-activity relationships showed that the number of methoxy groups, an optimal length of the mol. in its extended conformation, and at least one flexible methylene group bridging the quinolinone to the moiety bearing the pyrimidine favored the inhibitory potency of P-gp. The best compounds showed a similar binding pattern and interactions to those of doxorubicin and tariquidar, as revealed by MD and hybrid QM/MM simulations performed with the recent exptl. structure of P-gp co-crystallized with paclitaxel. Anal. of the mol. interactions stabilizing the different mol. complexes determined by MD and QTAIM showed that binding to key residues from TMH 4-7 and 12 is required for inhibition. After reading the article, we found that the author used 2,4-Dichloropyrimidine(cas: 3934-20-1Reference of 2,4-Dichloropyrimidine)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Reference of 2,4-Dichloropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia