Doll, Julianna S.; Eichelmann, Robert; Hertwig, Leif E.; Bender, Thilo; Kohler, Vincenz J.; Bill, Eckhard; Wadepohl, Hubert; Rosca, Dragos-Adrian published their research in ACS Catalysis in 2021. The article was titled 《Iron-Catalyzed Trimerization of Terminal Alkynes Enabled by Pyrimidinediimine Ligands: A Regioselective Method for the Synthesis of 1,3,5-Substituted Arenes》.Name: 2,4,6-Trichloropyrimidine The article contains the following contents:
The development of pyrimidine-based analogs of the well-known pyridinediimine (PDI) iron complexes e.g., I enables access to a functional-group-tolerant methodol. for the catalytic trimerization of terminal aliphatic alkynes RCC (R = 4-fluorophenyl, Bu, cyclopropyl, thiophen-2-yl, etc.). Remarkably, in contrast to established alkyne trimerization protocols, the 1,3,5-substituted arenes 1,3,5-R3C6H3 are the main reaction products. Preliminary mechanistic investigations suggest that the enhanced π-acidity of the pyrimidine ring, combined with the hemilability of the imine groups coordinated to the iron center, facilitates this transformation. The entry point in the catalytic cycle is an isolable iron dinitrogen complex. The catalytic reaction proceeds via a 1,3-substituted metallacycle, which explains the observed 1,3,5-regioselectivity. Such a metallacycle could be isolated and represents a rare 1,3-substituted ferracycle obtained through alkyne cycloaddition In the experimental materials used by the author, we found 2,4,6-Trichloropyrimidine(cas: 3764-01-0Name: 2,4,6-Trichloropyrimidine)
2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Name: 2,4,6-Trichloropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia