《Access to a new class of synthetic building blocks via trifluoromethoxylation of pyridines and pyrimidines》 was published in Chemical Science in 2016. These research results belong to Feng, Pengju; Lee, Katarzyna N.; Lee, Johnny W.; Zhan, Chengbo; Ngai, Ming-Yu. Name: 2-Methoxy-5-nitropyrimidine The article mentions the following:
A scalable and operationally simple protocol for regioselective trifluoromethoxylation of a wide range of functionalized pyridines I [R = 5-Br-6-OMe, 6-(1H-Benzo[d]imidazol-1-yl), 6-(1H-pyrazol-1-yl), etc.; R1 = OMe, Me; X = OH; Y = H] and pyrimidines II [R2 = (2-(Thiazol-4-yl)-1H-benzo[d]imidazol-1-yl), 2-OMe, 4-Cl-3,5-(Me)2-OC6H2, etc.; W = OH; Z = H] under mild reaction conditions is presented. The trifluoromethoxylated products I [X = H; Y = 2-OCF3, 4-OCF3] and II [W = H; Z = OCF3] are useful scaffolds that can be further elaborated by amidation and palladium-catalyzed cross coupling reactions. Mechanistic studies suggest that a radical O-trifluoromethylation followed by the OCF3 -migration reaction pathway is operable. The unique properties of the OCF3 group and the ubiquity of pyridine and pyrimidine in biol. active mols. and functional materials, trifluoromethoxylated pyridines I [X = H; Y = 2-OCF3, 4-OCF3] and pyrimidines II [W = H; Z = OCF3] could serve as valuable building blocks for the discovery and development of new drugs, agrochems., and materials. In the experiment, the researchers used many compounds, for example, 2-Methoxy-5-nitropyrimidine(cas: 14001-69-5Name: 2-Methoxy-5-nitropyrimidine)
2-Methoxy-5-nitropyrimidine(cas: 14001-69-5) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Name: 2-Methoxy-5-nitropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia