In 1977,Heterocycles included an article by Sakamoto, Takao; Konno, Shoetsu; Yamanaka, Hiroshi. Computed Properties of C6H8N2O. The article was titled 《Syntheses of pyrimidinyl ketones》. The information in the text is summarized as follows:
Acylpyrimidines were prepared by nitrosation of alkylpyrimidines and hydrolysis of the oximes. Nitrosation of methylpyrimidines and dehydration with POCl3 gave cyanopyrimidines which underwent Grignard reaction with EtMgBr to give ethyldihydropyrimidines. Some acetylpyrimidines were also obtained by homolytic acetylation and underwent Willgerodt-Kindler reaction to give pyrimidinethioacetamides. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Computed Properties of C6H8N2O)
2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Computed Properties of C6H8N2O
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia