In 2016,Galeta, Juraj; Sala, Michal; Dracinsky, Martin; Vrabel, Milan; Havlas, Zdenek; Nencka, Radim published 《Single-Step Formation of Pyrimido[4,5-d]pyridazines by a Pyrimidine-Tetrazine Tandem Reaction》.Organic Letters published the findings.Application In Synthesis of 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:
A straightforward synthesis of pyrimido[4,5-d]pyridazines from pyrimidines and tetrazines under basic conditions is reported. Deprotonated, substituted 5-halopyrimidines readily react with variously substituted tetrazines in a highly regioselective manner via a complex reaction pathway, which was supported by DFT calculations This mechanism leads to the empirically observed regioisomers without going through the conceivable hetaryne intermediate. These results on 5-halopyrimidines led to development of the methodol. for preparation of opposite regioisomers based on 6-halopyrimidines. After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Application In Synthesis of 2,4,6-Trichloropyrimidine)
2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Application In Synthesis of 2,4,6-Trichloropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia