213265-83-9, A common compound: 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine,molecular formula is C4HCl2FN2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Intermediate A39-2 (200mg, 1.07mmol) was dissolved in tetrahydrofuran (5mL), was added 4,6-dichloro-5-fluoropyrimidine (179mg, 1.07mmol),Diisopropylethyl amine (414mg, 3.21mmol), 50 stirred overnight, cooled to room temperature, spin dry solvent, the residue was purified by column chromatography (dichloromethane:Methanol = 150: 1) to give a colorless oil (240mg, 71%). 1HNMR (400MHz, CDCl3) delta8.23 (s, 1H), 7.51 (s, 1H),7.45-7.40 (m, 4H), 6.30 (s, 1H), 5.55 (s, 1H), 4.79 (d, J = 6.0Hz, 2H), 3.89 (s, 3H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 213265-83-9.
Reference:
Patent; Suzhou Yunxuan Pharmaceutical Co., Ltd.; Zhang, Xiaohu; (54 pag.)CN105254613; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia