Some common heterocyclic compound, 137234-74-3, molecular formula is C6H6ClFN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.137234-74-3
In a 500 mL three-necked flask, 150 mL of dichloroethane was added, 34.1 g of the chlorinated product prepared in the same manner as in the above step (3)1.5 g of azobisisobutyronitrile(AIBN) 28.4 g of N-bromosuccinimide(NBS) was dissolved in 50 mL of dichloroethane, Then drop into the reaction bottle, add dichloroethane 50mL. After the reaction solution was clarified, a mixed solution of 22.1 g of NBS dissolved in 100 mL of dichloroethane was added dropwise, and the mixture was heated to 50 C and reacted for 15 h. After the completion of the reaction, 100 mL of water was added to separate the aqueous phase and the organic phase. The aqueous phase was extracted with 80 mL of dichloroethane and the organic layers were combined. The organic layer was washed with sodium bisulfite solution and the organic layer was washed with water The organic layer was dried over anhydrous sodium sulfate,The solvent dichloroethane was distilled off under reduced pressure to obtain 52.6 g of the target compound 4-(1-bromoethyl)-5-fluoro-6-chloropyrimidine as a pale yellow liquid in a yield of 92%, and the purity of the high performance liquid chromatography was 86% .
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 137234-74-3.
Reference:
Patent; JUHUA Group Technology Center; YANG, JIANRONG; GE, CHENGSHENG; LI, JIAN; (8 pag.)CN103896855; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia