On November 30, 2019, Garlito, Borja; Ibanez, Maria; Portoles, Tania; Serrano, Roque; Amlund, Heidi; Lundebye, Anne-Katrine; Sanden, Monica; Berntssen, Marc H. G.; Hernandez, Felix published an article.Formula: C5H6N2O2 The title of the article was LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients. And the article contained the following:
The composition of Atlantic salmon feed has changed considerably over the last two decades from being marine-based (fishmeal and fish oil) to mainly containing plant ingredients. Consequently, concern related to traditional persistent contaminants typically associated with fish-based feed has been replaced by other potential contaminants not previously associated with salmon farming. This is the case for many pesticides, which are used worldwide to increase food production, and may be present in plant ingredients. Earlier studies have identified two organophosphorus pesticides, chlorpyrifos-Me and pirimiphos-Me, in plant ingredients used for aquafeed production In the present study, we developed a reliable and sensitive anal. method, based on liquid chromatog. coupled to tandem mass spectrometry, for the determination of these pesticides and their main metabolites in warm water (zebrafish) and cold water (Atlantic salmon) species, where possible differences in metabolites could be expected. The method was tested in whole zebrafish and in different salmon tissues, such as muscle, bile, kidney, fat, and liver. The final objective of this work was to assess kinetics of chlorpyrifos-Me and pirimiphos-Me and their main metabolites in fish tissue, in order to fill the knowledge gaps on these metabolites in fish tissues when fed over prolonged time. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Formula: C5H6N2O2
The Article related to lc ms organophosphorus pesticide bioaccumulation metabolite salmon zebrafish, plant based feed contamination salmo danio chlorpyrifos pirimiphos methyl, atlantic salmon, chlorpyrifos-methyl, lc-ms/ms, metabolites, pirimiphos-methyl, zebrafish and other aspects.Formula: C5H6N2O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia