On June 1, 2012, Li, Zhenhua; Wu, Danli; Zhong, Weihui published an article.Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine The title of the article was Facile and efficient cyclization of anthranilonitrile to 2,4-dichloroquinazoline by bis(trichloromethyl) carbonate and catalytic amount triphenylphosphine oxide. And the article contained the following:
2,4-Dichloroquinazolines were synthesized by the cyclization of anthranilonitrile using bis(trichloromethyl)carbonate with the aid of catalytic amount of Ph3PO at 120 °C. This method was also applied to the synthesis of 2,4-dichlorothieno[2,3-d]pyrimidine. The plausible mechanism was presented. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine
The Article related to anthranilonitrile chloromethylcarbonate cyclization phenylphosphine oxide catalyst, aminothiophenonitrile chloromethylcarbonate cyclization phenylphosphine oxide catalyst, chloroquinazoline preparation, chlorothienopyrimidine preparation and other aspects.Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia