On September 7, 2021, SenGupta, Tanima; Palikaras, Konstantinos; Esbensen, Ying Q.; Konstantinidis, Georgios; Galindo, Francisco Jose Naranjo; Achanta, Kavya; Kassahun, Henok; Stavgiannoudaki, Ioanna; Bohr, Vilhelm A.; Akbari, Mansour; Gaare, Johannes; Tzoulis, Charalampos; Tavernarakis, Nektarios; Nilsen, Hilde published an article.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione The title of the article was Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. And the article contained the following:
Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative pathologies, such as Parkinson disease (PD). Although genomic instability is associated with aging and mitochondrial impairment, the underlying mechanisms are poorly understood. Here, we show that base excision repair generates genomic stress, promoting age-related neurodegeneration in a Caenorhabditis elegans PD model. A physiol. level of NTH-1 DNA glycosylase mediates mitochondrial and nuclear genomic instability, which promote degeneration of dopaminergic neurons in older nematodes. Conversely, NTH-1 deficiency protects against α-synuclein-induced neurotoxicity, maintaining neuronal function with age. This apparent paradox is caused by modulation of mitochondrial transcription in NTH-1-deficient cells, and this modulation activates LMD-3, JNK-1, and SKN-1 and induces mitohormesis. The dependence of neuroprotection on mitochondrial transcription highlights the integration of BER and transcription regulation during physiol. aging. Finally, whole-exome sequencing of genomic DNA from patients with idiopathic PD suggests that base excision repair might modulate susceptibility to PD in humans. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
The Article related to caenorhabditis parkinson disease single stranded dna base excision repair, c. elegans, dna-glycosylase, nth-1, parkinson disease, aging, base excision repair, hydrogen peroxide, mitohormesis, neurodegeneration, oxidative dna damage and other aspects.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia