156-81-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 156-81-0, name is Pyrimidine-2,4-diamine. This compound has unique chemical properties. The synthetic route is as follows.
A solution of 2-bromo-1-(5-bromo-2,4-dimethoxyphenyl)ethanone 7 (62 mg, 0.0.21 mmol) and pyrimidine-2,4-diamine 164a (20 mg, 0.18 mmol) in acetone (5 ml) was heated to reflux for 3h. The reaction mixture was cooled to room temperature: the white precipitate was filtered and washed with acetone. The precipitate was suspended in aqueous ammonia (10 mL) and stirred for 30 mins. The precipitate was filtered, washed with water. The solid was converted to HCl salt by treating it to dilute HCl. The precipitate obtained dried under reduced pressure to yield 2-(5-bromo-2,4-dimethoxyphenyl)imidazo[l,2-a]pyrimidin-7-amine hydrochloride 164a (18 mg, 44%) as an off-white solid. 1H NMR (300 MHz, DMSO-ifc): delta 8.54- 8.52(d, ./ 7.6 Hz, 1H), 8.22 (br s, 2H), 8.11 (s, 1H), 8,07 (s, 1H), 6.92(s, 3H), 6,71-6.68(d, J= 7,6 Hz, 1H), 4.03 (s, 3H), 3 ,97 (s, 3H). HPLC (Method 3} 97.8% (AUC), = 16.84 min; APCI MS m/z 351 [M +2+ i l l .
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 156-81-0, Pyrimidine-2,4-diamine.
Reference:
Patent; ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; CHAKRABARTI, Anjan; RAWAT, Manish; RAI, Sanjay; SATYANARAYANA, Arvapalli, Venkata; DUAN, Zhiyong; TALUKDAR, Arindam; RAVULA, Srinivas; DECORNEZ, Helene; (491 pag.)WO2017/58503; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia