Dahabiyeh, Lina A.; Mujammami, Muhammad; Arafat, Tawfiq; Benabdelkamel, Hicham; Alfadda, Assim A.; Abdel Rahman, Anas M. published an article in 2021, the title of the article was A metabolic pattern in healthy subjects given a single dose of metformin: a metabolomics approach.Electric Literature of 4433-40-3 And the article contains the following content:
Metformin is a widely prescribed medication for the treatment of type 2 diabetes mellitus (T2DM). It possesses effective roles in various disorders, including cancer, dyslipidemia, and obesity. However, the underlying mechanisms of metformin′s multiple benefits are not fully understood. Herein, a mass spectrometry-based untargeted metabolomics approach was used to investigate the metabolic changes associated with the administration of a single dose of metformin in the plasma of 26 healthy subjects at five-time points; pre-dose, before the maximum concentration of metformin (Cmax), Cmax, after Cmax, and 36 h postdose. A total of 111 metabolites involved in various biochem. processes were perturbed, with branched-chain amino acid (BCAA) being the most significantly altered pathway. Addnl., the Pearson similarity test revealed that 63 metabolites showed a change in their levels dependent on metformin level. Out of these 63, the level of 36 metabolites was significantly altered by metformin. Significantly altered metformin-dependent metabolites, including hydroxymethyl uracil, propionic acid, glycerophospholipids, and eicosanoids, pointed to fundamental biochem. processes such as lipid network signaling, energy homeostasis, DNA lesion repair mechanisms, and gut microbiota functions that could be linked to the multiple beneficial roles of metformin. Thus, the distinctive metabolic pattern linked to metformin administration can be used as a metabolic signature to predict the potential effect and mechanism of actions of new chem. entities during drug development. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Electric Literature of 4433-40-3
The Article related to metabolic pattern healthy human single dose metformin metabolomics, branched-chain amino acids, cancer, eicosanoids, glycerophospholipid, mass spectrometry, metabolomics, metformin, type 2 diabetes mellitus and other aspects.Electric Literature of 4433-40-3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia