Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Category: pyrimidines.
Ma, You-Zhen;Tang, Zhen-Bo;Sang, Chun-Yan;Qi, Zhi-Yuan;Hui, Ling;Chen, Shi-Wu research published 《 Synthesis and biological evaluation of nitroxide labeled pyrimidines as Aurora kinase inhibitors》, the research content is summarized as follows. To find novel effective Aurora kinases inhibitors, a series of structurally interesting nitroxide labeled pyrimidines I (R = cyclopentylamino, morpholin-4-yl, 3-[(4-nitrophenyl)amino]propylamino, etc.; R1 = NO2, F) was synthesized and evaluated for their anti-proliferative and Aurora kinases inhibitory activities. Among them, I (R = [5-(2-butoxy-2-oxoethyl)-1H-pyrazol-3-yl]aminyl; R1 = F) possessed the most potent anti-proliferative effects against four carcinoma cell lines with IC50 values in range of 0.89-11.41 μM, and kinases inhibition against Aurora A and B with the IC50 values were 9.3 and 2.8 nM, resp. Furthermore, I (R = [5-(2-butoxy-2-oxoethyl)-1H-pyrazol-3-yl]aminyl; R1 = F) blocked the phosphorylation of Aurora A (T288), Aurora B (Thr232) and HisH3, decreased the expression of proteins TPX2, Eg5 and Bora, as well as disrupted the mitotic spindle formation in HeLa cells. Mol. docking studies indicated that I (R = [5-(2-butoxy-2-oxoethyl)-1H-pyrazol-3-yl]aminyl; R1 = F) well interact with both Aurora A and B. The results showed that I (X = F; R = [5-(2-butoxy-2-oxoethyl)-1H-pyrazol-3-yl]aminyl) is a potential anticancer agent as promising pan-Aurora kinase inhibitor.
Category: pyrimidines, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia