The common heterocyclic compound, 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 49845-33-2
A mixture of 2,4-dichloro-5-nitropyrimidine (3.86 g, 20 mmol)Iron powder (5.6 g, 100 mmol)Was added to glacial acetic acid (50 mL)Stir at room temperature for 6 h.Add ethyl acetate to dilute,Filter,The filtrate was washed with saturated aqueous sodium carbonate solution,Saturated salt water wash,dry,Spin dry,To give a crude product of 3.3 g.
The synthetic route of 49845-33-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KBP Biosciences Co., Ltd.; Zhang, Qian; Zhang, Yan; (50 pag.)CN103864792; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia