The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Product Details of C4H5N3.
Rehan, Thamer A.;Al-Lami, Naeemah;Alanee, Rafal Shakeeb research published 《 Anti-cancer and antioxidant activities of some new synthesized 3-secondary amine derivatives bearing imidazo[1,2-a]pyrimidine》, the research content is summarized as follows. In this study, new series of 2-aryl-3-(pyrimidin-2-ylamino)imidazo[1,2-a]pyrimidine derivatives I (R = H, Br, NO2, OH, NH2; R1 = H) were synthesized through one-pot reaction of aromatic ketones 4-RC6H4C(O)Me and 2-aminopyrimidine. These reactions were performed in the presence of I2 and DMSO. Derivatives of 3-amine compound I were reacted with propargyl bromide to yield 2-phenyl-N-(prop-2-yn-1-yl)-N-(pyrimidin-2-yl) derivatives of imidazo/pyrimidine rings. I (R1 = CH2CCH). Then, by Mannich reaction, one of 3-secondary amine derivatives I (R = NH2, R1 = H) was reacted with different aromatic amines to form Mannich bases II (R2 = benzo[d]thiazol-2-ylamino, morpholino, 2-methoxy-4-nitrophenylamino, etc.). Other derivatives of imidazo(1,2-a)pyrimidine I (R = NO2, R1 = H; R = NO2, R1 = CH2CCH; R = NHCH2CCH, R1 = CH2CCH), II (R2 = 2-methoxy-4-nitrophenylamino) were evaluated for anti-oxidant activity and one of these derivatives I (R = NHCH2CCH, R1 = CH2CCH) was tested for cytotoxic activity against breast cancer using MTT assay.
Product Details of C4H5N3, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia