The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Formula: C4H5N3.
Shukla, Pratibha;Deswal, Deepa;Narula, Anudeep Kumar research published 《 Monomeric silica supported interaction of TOSMIC with highly functionalized imines: A green approach to azetidines via ABB -type cycloaddition reaction》, the research content is summarized as follows. The reaction of TOSMIC with highly functionalized imines R1CH=NR2 (R1 = Ph, Pr, 1-naphthyl, etc.; R2 = 2-pyridyl, pyrimidin-2-yl, pyrazin-2-yl, 1,3-thiazol-2-yl) has been reported. The use of monomeric silica as a catalyst for the reaction has been reported for the first time. The main product of the reported green methodol., formed by the sequential attack of the two TOSMIC units upon the carbon-nitrogen double bond of highly functionalized imines, has been identified as bis(tosylmethyl)azetidines I, a four member N-heterocyclic system. The scope of the reaction concerning functionalized imines and TOSMIC reactivity has been studied and determined, keeping in view the advantage of using TOSMIC as component B for the ABB-type cycloaddition reactions.
Formula: C4H5N3, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia